RESEARCH STUDY:

Join a Research Study Tracking Brain Activity During Depression Treatment

Are you currently receiving treatment for depression? You may qualify for a research study about how the brain responds to treatment for major depressive disorder (MDD).

Get Started

Acacia Clinics is conducting a research study using an investigational non-invasive electroencephalogram (EEG) headset that records brain activity during SPRAVATO or TMS treatment. This will help researchers explore how changes in brain activity relate to treatment response.

This is an independent, investigator-initiated study. The device shown is FDA-cleared for certain uses, but not for the condition being studied. Its use here is research only and is not promoted or endorsed by Ceribell.

CAUTION: Device does not substitute for EEG review by a qualified clinician. Before use, review the manual for indications, contraindications, warnings, precautions, potential adverse events, and Instructions for Use. Sale requires the order of a physician.

Image provided by Ceribell, Inc.

Have you been diagnosed with Major Depressive Disorder? Are you starting a new treatment like SPRAVATO or TMS?

This study uses an FDA-cleared EEG system (from Ceribell, Inc.) that is comfortable, portable, and easy to use. Participants will complete brief mood questionnaires and wear a soft headband device that non-invasively records brain signals at rest or during treatment

Study duration: up to 1 month depending on your treatment
EEG recording sessions: 1–3 visits depending on your cohort
Location: All EEG visits take place at Acacia Clinics. Follow-up visits may be remote.

Study Experience:

What’s involved?

Complete mood and symptom surveys (before, during, or after treatment)
Wear a lightweight EEG headset during designated timepoints
rTMS participants: EEG at baseline, midpoint, and at the end of treatment
SPRAVATO participants: EEG before, during, and after one session
Optional follow-up surveys at 1 week and 1 month after treatment

Length of Study

Up to 1 month depending on your treatment

Number of Study Visits

1–3 visits depending on your cohort

Image provided by Ceribell, Inc.

Eligibility (Main Criteria):

Adults aged 18+ (up to 75 for SPRAVATO)
Primary diagnosis of Major Depressive Disorder (MDD)
Starting TMS or SPRAVATO at Acacia Clinics
Willing to complete brief surveys and EEG sessions
Able to provide informed consent and communicate in English

Study purpose:

E-TEMPO is an observational study exploring how the brain responds to treatments for depression, including repetitive Transcranial Magnetic Stimulation (rTMS) and SPRAVATO (esketamine nasal spray). The study uses non-invasive electroencephalogram (EEG) technology (from Ceribell Inc.) to identify patterns in brain activity that may help predict treatment outcomes in the future.

Interested in participating?

Contact our research team:

For more information, give us a call at (650) 993-9397 or email us at research@acaciaclinics.com.

FAQ

EEG stands for electroencephalography, a non-invasive method of recording brain activity using small sensors placed on the scalp.
There is no cost to you to participate in this EEG study. You may have costs related to your treatment, which is not part of this research.
No. Your treatment will proceed as usual. This is an observational study.
Study visits are scheduled to align with your regular treatment schedule whenever possible.
The EEG device is FDA-cleared, non-invasive, and does not introduce any energy into the body.
The FDA-cleared EEG system is provided by Ceribell, Inc., a medical technology company.
The Ceribell system used in this study is FDA-cleared to record and store EEG signals. In this research, it is being used for exploratory purposes and to help us better understand how brain activity relates to depression treatment.